Autoimmune polyendocrine syndrome type 2
Autoimmune polyendocrine syndrome type 2 is a form of autoimmune polyendocrine syndrome.
Autoimmune polyendocrine syndrome, type 2 (also known as "Schmidt's syndrome",[1] or APS-II) is the most common form of the polyglandular failure syndromes.[2] It is more heterogeneous and has not been linked to one gene. Rather, patients are at a higher risk when they carry a particular human leukocyte antigen genotype (DQ2, DQ8 and DRB1*0404). APS-II affects women to a greater degree than men (75% of cases occur in women).[2]
Features of this syndrome are:
Symptoms
Symptoms of Addison's Disease and Hashimoto's Thyroiditis include:
- Dry hair
- Nausea
- Abdominal Pain
- Frequent Urination
- Vomiting
- Weight and Muscle Loss
- Salt Cravings
- Anorexia and cachexia
- High Pulse/Weakened Heart
- Low Blood Pressure
- Weakness
- Hypoglycemia
- Numbness in Extremities
- Migraines
- Poor Immune System Response - Lacking Natural Bodily Inflammatories
Some researchers favour splitting this syndrome into three distinct syndromes (numbering 2, 3[4] and 4), but research evidence for these distinct combinations is not convincing.
References
- ^ Heuss D, Engelhardt A, Göbel H, Neundörfer B (June 1995). "Myopathological findings in interstitial myositis in type II polyendocrine autoimmune syndrome (Schmidt's syndrome)". Neurol. Res. 17 (3): 233–7. PMID 7643982.
- ^ a b Greenspan, Francis S.; Gardner, David C. (2004). Basic clinical endocrinology. New York: McGraw-Hill. pp. 103. ISBN 0-07-140297-7.
- ^ Betterle C, Zanchetta R (April 2003). "Update on autoimmune polyendocrine syndromes (APS)". Acta Biomed 74 (1): 9–33. PMID 12817789.
- ^ de Carmo Silva R, Kater CE, Dib SA, et al (February 2000). "Autoantibodies against recombinant human steroidogenic enzymes 21-hydroxylase, side-chain cleavage and 17alpha-hydroxylase in Addison's disease and autoimmune polyendocrine syndrome type III". Eur. J. Endocrinol. 142 (2): 187–94. doi:10.1530/eje.0.1420187. PMID 10664529. http://eje-online.org/cgi/pmidlookup?view=long&pmid=10664529. Retrieved 2008-07-25.